Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants

Maimonides Medical Center

Status: Completed

Conditions: Respiratory Distress Syndrome

Treatments: Other: Gradual pressure wean

Study type: Interventional

Funder types: Other

Identifiers

NCT02126501

MMC 13/01/VA03

Details and patient eligibility

About

To compare the 2 methods of weaning of nasal continuous positive airway pressure (CPAP) in premature babies born between 26 and 32 weeks

Full description

To study the weight and the post menstrual age (PMA) at the time of NCPAP wean utilizing the method of sudden wean as compared to gradual wean.

Methods: A prospective randomized trial was conducted comparing sudden weaning with gradual weaning from NCPAP in neonates with gestational age between 26 and 32 weeks. The patients were randomized to one of the two methods of weaning from NCPAP and their success was compared

Enrollment: 70 patients

Sex: All

Ages: 26 to 32 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All neonates born 26 to 32 weeks of gestational age

Exclusion criteria

• Those with severe congenital anomalies and chromosomal defects including congenital heart disease, neurological malformations, chest and airway abnormalities and lung hypoplasia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

Sudden wean

No Intervention group

Description:

When ready Nasal Continuous Positive Airway Pressure (NCPAP) will be removed from the neonate

Gradual pressure wean

Active Comparator group

Description:

NCPAP will be removed by gradually decreasing pressure over 24 hours once the weaning is decided

Treatment:

Other: Gradual pressure wean