Comparision of the Clinical Efficacy of Different Desensitizing Toothpastes

Altinbas University

Status: Completed

Conditions: Dentine Hypersensitivity

Treatments: Other: Nano-Hydroxyapatite; Other: 8% Arginine & Calcium Carbonate; Other: Sodium Monofluorophosphate; Other: Stannous Fluoride

Study type: Interventional

Funder types: Other

Identifiers

NCT06197555

2022/138

Details and patient eligibility

About

Dentin hypersensitivity is a common problem in society. Untreated hypersensitivity affects the patient's quality of life, complicates plaque control and increases the risk of caries and periodontal disease. This study aimed to evaluate the clinical efficacy of desensitizing toothpastes containing sodium fluoride, stannous fluoride, nano-hydroxyapatite, 8% arginine and calcium carbonate.

Fourty eight patients with at least two teeth with positive responses to air and mechanical stimulus were included in the study and were divided into four groups. Sodium fluoride (Colgate®, Cavity Protection) in group A, stannous fluoride (Oral B® Gum Calm & Sensitivity) in group B, nano-hydroxyapatite (ApaCare®) in group C and 8% arginine and calcium carbonate combination in group D (Colgate® Sensitive Pro- ReliefTM) were used by the patients continuously for 16 weeks. Dentin hypersensitivity, by using VAS and Shiff scores and periodontal parameters were evaluated at baseline, 2nd week, 4th week and last 16th week.

Enrollment: 48 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Dentin hypersensitivity complaints
• Systemically healthy
• Not during pregnancy & lactation
• No sensitivity treatment in the last 6 months
• Forty-eight patients with positive response to VAS and Schiff tests were included.

Exclusion criteria

People who have;

• Any systemic disease
• Take regular medication for any other reason
• Undergone periodontal surgery within the last 6 months,
• History of allergy to toothpaste materials,
• Active caries, restoration and/or bridge on the sensitive tooth,
• Orthodontic appliances,

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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48 participants in 4 patient groups

Group A (Sodium Monofluorophosphate)

Active Comparator group

Description:

Dentifrice containing Sodium Monofluorophosphate, daily homecare usage Colgate®, Cavity Protection

Treatment:

Other: Sodium Monofluorophosphate

Group B (Stannous Fluoride)

Active Comparator group

Description:

Dentifrice containing Stannous Fluoride, daily homecare usage Oral B®, Gum Calm \& Sensitivity

Treatment:

Other: Stannous Fluoride

Group C (Nano-Hydroxyapatite)

Active Comparator group

Description:

Dentifrice containing Nano-Hydroxyapatite, daily homecare usage ApaCare®

Treatment:

Other: Nano-Hydroxyapatite

Group D (8% Arginine & Calcium Carbonate)

Active Comparator group

Description:

Dentifrice containing 8% Arginine \& Calcium Carbonate, daily homecare usage Colgate®, Sensitive Pro-Relief

Treatment:

Other: 8% Arginine & Calcium Carbonate