Comparisom of Liquid Nitrogen and Vitamin D3 in The Treatment of Cutaneous Warts

Combined Military Hospital Abbottabad

Status and phase: Completed; Phase 1

Conditions: Cutaneous Warts

Treatments: Drug: intralesional vitamin D3; Drug: liq nitrogen

Study type: Interventional

Funder types: Other

Identifiers

NCT05739786

CMHAtd-ETH-17-DERM-22

Details and patient eligibility

About

A total of 60 female patients (30 patients in each group) with cutaneious warts diagnosed by a consultant dermatologist on physical examination were included in this study.

In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) while patients in Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness in both groups was ascertained in terms of > 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient of cutaneous warts presented in dermatology department.

Exclusion criteria

• Immunosuppressed patients
• chronic skin diseases like eczema or autoimmune disease
• diabetes mellitus
• cold sensitivity , skin allergies
• pregnancy, and lactation
• periungual warts

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Group A liquid nitrogen

Active Comparator group

Description:

liquid nitrogen In Group A patients were subjected to liquid nitrogen cryotherapy (-196 0C) for 3 sessions at every 3 weeks interval. Effectiveness in was ascertained in terms of \> 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.

Treatment:

Drug: liq nitrogen

Group B intralesional Vit D3

Active Comparator group

Description:

intralesional Vit D3 Group B were subjected to vitamin D3 (5mg/ml) for 3 sessions at every 3 weeks interval. Effectiveness was ascertained in terms of \> 50% reduction in wart size by an expert dermatologist on physical examination at the end of third session. Patients were followed for further 6 weeks after last session to look for any sort of recurrence and remission.

Treatment:

Drug: intralesional vitamin D3