Comparison Across Multiple Types of Sleep Deprivation

Civil Aerospace Medical Institute

Status: Completed

Conditions: Sleep Restriction; Sleep Deprivation

Treatments: Behavioral: Controlled sleep

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT04211506

GEN10025

Details and patient eligibility

About

This study is designed to assess neurobehavioral performance, as well as genetic and other physiological changes associated with variations in timing and quantity of sleep.

Full description

During a 1.5 week inpatient laboratory protocol, subjects will undergo one of four parallel sleep conditions. Subjects will be randomly assigned to each condition group. During their time in the laboratory, biological samples (e.g., blood) will be collected for genetic and other analyses, and sleep quantity and quality will be monitored. Additionally responses on neurobehavioral tests and surveys will be monitored for differences among the groups.

Enrollment: 59 patients

Sex: All

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• BMI 18.5-29.9, with consideration of BMIs 30-34.9.

Exclusion criteria

• Medication use, with potential consideration for contraceptives.
• Color blindness
• Recent nightwork, shiftwork, or travel across greater than two time zones
• Pregnant or within 6 months post-partum

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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59 participants in 4 patient groups

Sleep Arm 1

Experimental group

Description:

This will be the first of four arms of controlled sleep manipulation.

Treatment:

Behavioral: Controlled sleep

Sleep Arm 2

Experimental group

Description:

This will be the second of four arms of controlled sleep manipulation.

Treatment:

Behavioral: Controlled sleep

Sleep Arm 3

Experimental group

Description:

This will be the third of four arms of controlled sleep manipulation.

Treatment:

Behavioral: Controlled sleep

Sleep Arm 4

Experimental group

Description:

This will be the fourth of four arms of controlled sleep manipulation.

Treatment:

Behavioral: Controlled sleep