Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With Frenectomy

Yonsei University

Status: Completed

Conditions: Ankyloglossia

Treatments: Drug: administration of propofol; Drug: administration of rocuronium; Drug: administration of alfentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT01550354

4-2011-0824

Details and patient eligibility

About

Several methods have been demonstrated to improve intubating conditions during sevoflurane induction in children. These include opioids, propofol, and addition of neuromuscular blocking agents in pediatric patients. But the study about the comparison of these agents has been uncommon. Frenectomy is common procedure to treat ankyloglossia. It is a short procedure performed under general anesthesia. The investigators aimed to compare intubating conditions among children with propofol, alfentanil or rocuronium after sevoflurane induction.

Enrollment: 114 patients

Sex: All

Ages: 1 to 9 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children, 1-9 years old scheduled elective frenectomy under general anesthesia

Exclusion criteria

• Patients with an abnormal airway, reactive airway disease, gastroesophageal reflux disease, chronic respiratory disease, or a history of an upper respiratory tract infection in the preceding 6-week period

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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114 participants in 3 patient groups

Propofol group

Active Comparator group

Description:

Intravenous administration of propofol 2 mg/kg before intubation

Treatment:

Drug: administration of propofol

Alfentanil group

Active Comparator group

Description:

Intravenous administration of alfentanil 14 μg/kg before intubation

Treatment:

Drug: administration of alfentanil

Rocuronium group

Active Comparator group

Description:

Intravenous administration of rocuronium 0.3 mg/kg before intubation

Treatment:

Drug: administration of rocuronium