Comparison b/w Carbamazepine vs Oxcarbazepine in Treatment of Trigeminal Neuralgia

Abbasi Shaheed Hospital

Status: Active, not recruiting

Conditions: Trigeminal Neuralgia

Treatments: Drug: oxcarbazepine; Drug: Carbamazepine

Study type: Interventional

Funder types: Other

Identifiers

NCT07252453

IRB/KMDC/KMU/128/2025

Details and patient eligibility

About

In this Study investigator is comparing the effectiveness and outcomes of two drugs used un the treatment of trigeminal neuralgia , Carbamazepine vs Oxcarbazepine

Full description

In this open pilot open label randomized controlled trial, Investigator is comparing the effectiveness and outcomes of two drugs used un the treatment of trigeminal neuralgia, Carbamazepine vs Oxcarbazepine , hypothesis would be that oxcarbazepine has equal or better outcomes comparatively with less side effects

Enrollment: 122 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Inclusion Criteria:

  • Age 18-60 years
  • Either gender
  • TGN diagnosis for ≥2 weeks (according to ICHD-3 criteria¹)

Exclusion Criteria [Expanded]:

• Other cranial neuralgias
• Prior surgical treatment for TN
• Hepatic/renal dysfunction
• Epilepsy
• Pregnant/lactating women
• Drug allergy or intolerance
• [Expanded] Uncontrolled hypertension
• [Expanded] Psychiatric disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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122 participants in 2 patient groups

Carbamazepine group

Active Comparator group

Description:

In this group participants has been prescribed with carbamazepine which is conventional drug for trigeminal neuralgia management

Treatment:

Drug: Carbamazepine

Oxcarbazepine group

Active Comparator group

Description:

In this group participants has been prescribed with oxcarbazepine which is new FDA approved drug for TGN management

Treatment:

Drug: oxcarbazepine