Comparison Between Atenolol,Propnalol and Ivabradine

Menoufia University

Status: Completed

Conditions: Intraoperative Bleeding

Treatments: Drug: Propranolol Pill; Drug: Ivabradine; Drug: Atenolol 50 MG

Study type: Interventional

Funder types: Other

Identifiers

NCT06670690

9/2023ANET 13

Details and patient eligibility

About

The aim of this work is to compare atenolol, propranolol, and ivabradine as a premedication to achieve bloodless field anesthesia primarily controlling heart rate in lumbar spine surgery.

Full description

This study will investigate the effect of atenolol, propranolol, and ivabradine as oral premedication in adult patients undergoing LUMBAR SPINE SURGERY to achieve bloodless field anesthesia.

AIM OF THE WORK

• The primary aim of this work is to compare atenolol, propranolol, and ivabradine as a premedication to achieve bloodless field anesthesia primarily controlling heart rate in lumbar spine surgery.
• The secondary aims are to assess field visibility and measure the amount of blood loss in patients, and surgeon satisfaction and also to asses if there are any associated undesirable side effects of atenolol, propranolol, or Ivabradine will appear.

Enrollment: 120 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA physical status I and II,

  • aged from 18 to 50 years old
  • scheduled for elective lumber spine surgeries will be included in this study.

Exclusion criteria

• Hypertension.
• Hepatic or renal disease.
• Diabetes Mellitus.
• Pregnancy.
• Coagulation disorders.
• Anemia (Hb < 10 g/dL).
• Ischemic heart disease
• Drug or alcohol abuse.
• Allergy to any of atenolol, propranolol, and ivabradine.
• History of beta-blockers, calcium channel blockers, Tricyclic antidepressants, anticoagulant or clonidine intake.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 3 patient groups

Atenolol Group

Active Comparator group

Description:

patients will be premedicated with atenolol (50mg)

Treatment:

Drug: Atenolol 50 MG

propranolol Group

Active Comparator group

Description:

patients will be premedicated with propranolol (10mg)

Treatment:

Drug: Propranolol Pill

Ivabradine Group

Active Comparator group

Description:

patients will be premedicated with Ivabradine (5mg)

Treatment:

Drug: Ivabradine