Comparison Between Continuous Versus Interval Exercise Training in Asthmatic Patients

University of Sao Paulo General Hospital

Status: Unknown

Conditions: Asthma

Treatments: Other: Continuous Exercise Training; Other: Interval Exercise Training; Behavioral: Education Program

Study type: Interventional

Funder types: Other

Identifiers

NCT02489383

Asthmatic exercise training

Details and patient eligibility

About

The treatment of asthma is based in clinical control. However, previous studies have been shown that patients that participate of the programs of regular or aerobic continuous exercise training (CT) presented improvements in the physical conditioning, and quality life, as well as decreased the levels of anxiety and depression, reduced the oxide nitric exhaled and leukocyte migration at the airways and reduced the airway hyperresponsiveness. The regular exercise also is important part in the rehabilitation of other lung disease as well as chronic obstructive pulmonary disease (COPD). Additionally, others studies have been shown the effects of high intensity interval training (IT) in the pulmonary rehabilitation of COPD patients, that after performed IT presented reduction of dyspnea, and increase the physical capacity. In this sense, the impact of IT in the asthmatic patients at the present moment is poorly studied, and necessity of the more investigation to prove the efficiency of this training model for asthma patients.

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Full description

The present study will compare the impact of IT and CT in patients with moderate or severe asthma, and investigate what is the most efficient and increases the physical capacity, and quality of life and reduces the inflammatory mediators.

Sixty asthmatic adults will be randomly assigned into two groups: CT (Continuous training) or IT (Interval training). CT will have treatment 2x week, 40 min./session, 60-75% of maximum heart rate intensity and IT also 2x week, 40 min./session, 80-140% of the maximum load intensity, both performed in ergometer cycle by 24 weeks.

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Asthma moderate and severe
• Asthma will diagnosed (Global Initiative for Asthma - GINA)
• Body Mass Index (BMI) < 35kg/m2
• Medical Treatment for at least 6 months
• Clinically stable (i.e., no exacerbation or medication changes for at least 30 days)

Exclusion criteria

• Cardiovascular, musculoskeletal or other different chronic lung diseases
• Active cancer
• Pregnant
• Smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Continuous Exercise Training

Active Comparator group

Description:

The interventions of active comparator will be education program and exercise training.

Treatment:

Other: Continuous Exercise Training

Behavioral: Education Program

Interval Exercise Training

Active Comparator group

Description:

The interventions of active comparator will be education program and exercise training.

Treatment:

Other: Interval Exercise Training

Behavioral: Education Program