Comparison Between CT and MRI in Preoperative Evaluation of Neurogenic Myositis Ossificans or Neurogenic Para-osteo-arthritis (MON-IRM)

Assistance Publique - Hôpitaux de Paris

Status

Completed

Conditions

Neurogenic Myositis Ossificans

Neurogenic Para-osteo-arthritis

Treatments

Other: MRI examination

Other: CT scan

Study type

Interventional

Funder types

Other

Identifiers

NCT03832556

2018-A02783-52

Details and patient eligibility

About

The principal objective of the study is to compare between CT and MRI diagnostic performance (sensibility and specificity) in the preoperative assessment of neurogenic para-osteo-arthritis.

The second objectives of the study are:

besides the diagnostic performance (sensibility and specificity), to evaluate the imaging par MRI in visual and descriptive manner heterotopic ossification and connection with vascular and nervous structures.
to study the concordance (two by two) of results of preoperative obtained by MRI and by CT and operative reports.
to study the characteristics of patients with discordant findings (two by two) by MRI, CT scan and operative report.

Full description

This is a study on diagnostic performance, non randomized, versus Gold standard (a prospective multicentric cohort).

All eligible patients will be proposed consecutively to participate to the study, to undergo preoperative CT scan and MRI examination as usual procedure. The only additional action in this study will be a neurography sequence of type fluorescence subtraction imaging (FSI) during MRI, permitting to obtain more details in visualization of nerve structure and their relations of the ossifications.

The enrollment visit will performed by neuro-orthopaedic surgeon during preoperative consultation.

The follow-up visit will be an usual post-operative visit, non-specific for the study.

The duration for each participant will compound 1 month (the duration between preoperative imaging and surgical resection) added by up to two months of post-operative follow-up.

Enrollment

23 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult patient with neurogenic para-osteo-arthropathy resulted by prior central nervous system, cerebral or medullar damage
Deformation with limitation of articular amplitude which could result limitation in rehabilitation care
An indication of partial or total surgical excision of heterotopic ossification
Indication of pre-operative assessment by CT scan and MRI, with contrast product injection
Signed consent of patient obtained after clear and relevant informations given by physician
Patient covered by social security

Exclusion criteria

Contraindications to an MRI examination: cardiac stimulator, metallic intraocular foreign bodies...
Contraindications to CT scan
Contraindications to contrast injection product, such as iodinated or gadolinium-based contrast media
Impractical venous access
Severe deformation resulting impossibility to positioning for MRI examination or CT scan
Patient can not give consent
Participation to another interventional study
Patient under guardianship