Comparison Between Different Doses of Steroids in COVID-19 Patients

Ain Shams University

Status: Completed

Conditions: Critical Illness; Pneumonia, Viral

Treatments: Other: observation for outcome of methylprednisolone dose

Study type: Observational

Funder types: Other

Identifiers

NCT05279482

MS41/2022

Details and patient eligibility

About

aim of this study is to compare between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate, percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

Full description

Retrospective study for comparison between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate ,percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

Previous studies suggested that cytokine release syndrome could be involved in the pathophysiology of critical SARS.COV.2 resulting in death so early suppression of cytokine storm may be lifesaving in critical patients.

Enrollment: 104 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All icu admitted covid 19 patients with positive PCR, diagnosed by CT chest and needing oxygen therapy

Exclusion criteria

• Not requiring oxygen therapy
• Negative PCR
• Uncontrolled blood sugar or DKA
• Patients on long term steroids therapy

Trial design

104 participants in 2 patient groups

group treated with standard dose methyl prednisolone

Description:

patients with positive PCR and requiring oxygen therapy

Treatment:

Other: observation for outcome of methylprednisolone dose

group treated with mega dose methyl prednisolone

Description:

patients with positive PCR and requiring oxygen therapy

Treatment:

Other: observation for outcome of methylprednisolone dose