Comparison Between Drugs for Control of Emetic Attacks During Caesarean Delivery

Sohag University

Status: Not yet enrolling

Conditions: Emetic Attacks During Caesarean Delivery With Spinal Anesthesia

Treatments: Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT06300346

Soh-Med-23-12-02MS

Details and patient eligibility

About

Single shot spinal anesthesia is widely used for most surgical operations especially in obstetric such as hysterectomy, tubal ligation after vaginal delivery, cesarean and curettage etc.; however, in general, cesarean is considered as the most common indication for spinal anesthesia in pregnant women Intra-operative nausea and vomiting/retching (NVR) may be experienced by 20% to 80% of women undergoing cesarean section (CS) with subarachnoid anesthesia (SA) in the absence of antiemetic prophylaxis.

Different treatment options are available to reduce post operative nausea and vomiting (PONV) so we will make a Comparison between Propofol, Ondansetron and Pregabalin for Control of Emetic Attacks during Caesarean Delivery with Spinal Anesthesia

Enrollment: 90 estimated patients

Sex: Female

Ages: 21 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: 21-40 years old.
• Physical status American Society of Anesthesiologists (ASA)I&II.
• Body mass index (BMI) < 35&>20 kg/m2.
• Elective uncomplicated cesarean section under spinal anesthesia.

Exclusion criteria

• Patient refusal.
• Patients with known history of allergy to study drugs.
• Advanced hepatic, renal and respiratory diseases.
• Psychological and mental disorders.
• Patient with reduced level of consciousness.
• Hypertensive, cardiac, and diabetic patients.
• Patients receiving anticoagulants therapy or suspected coagulopathy.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 3 patient groups

propofol

Active Comparator group

Description:

30 Patients will receive propofol as equal volumes of both 1% of propofol 10mg/ml and0.9% normal saline will be drawn in a 20-ml syringe before spinal puncture.

Treatment:

Drug: Propofol

pregabalin

Active Comparator group

Description:

30 Patients will receive three capsules of pregabalin 100 mg once one hour before the surgical incision.

Treatment:

Drug: Propofol

ondansetron

Active Comparator group

Description:

30 Patients will receive 4 mg ondansetron in 10 ml saline intravenously 5 min before spinal puncture.

Treatment:

Drug: Propofol