Comparison Between Early Excision and Grafting Versus Dressing and Delayed Grafting in Deep Burn Mangement.

Sohag University

Status: Unknown

Conditions: Burns

Treatments: Procedure: dressing then delayed grafting; Procedure: Excision and Grafting

Study type: Interventional

Funder types: Other

Identifiers

NCT04965883

Soh-Med-21-06-08

Details and patient eligibility

About

• All the patients will be included in the study will be resuscitated on arrival in our department.
• Detailed history will be taken and burn evaluation will take place in respect to TBSA according to Lund and Browder chart and burn depth.
• Dreesing will be done with topical antimicrobial agent.
• Fluid resuscitation with lactated Ringer's solution according to modified Parkland's formula.
• Injectable proton pump inhibitors, and analgesics will be started as initial drug therapy.
• Close follow up of the patients will be done then evaluation of the patients will be done in the fourth day and dividing the patients into two groups: the first group "early exicion and grafting " and the second group " dressing and delayed grafting ".
• The first group will include patients with early surgery from 4 to 10 days since burn.
• Dressing will be done for the second group every other day until spontanous eschar seperation or after surgiacl debridrment of adherent eschar then for delayed grafting more than 10 days post burn.
• Then the data will be collected and analyzed for comparison between the two groups regarding : the timing of operation and its relation to the length of stay, functional outcome and cost of treatment

Full description

• The first group will include :

  1. Patients with good general condition and hemodynamically stable that fit for early surgery.
  2. Patients that accept the option of early surgery and can give consent for it .
  3. Patients with available donor site for early grafting.
  4. Patients with burn at certain sites may be of priority for early excision and grafting to avoid long term complication of delayed wound healing such as : on joint surface, hands, feet, and face.

• The early excision will be done surgically within 4-10 days post burn by whatson knife by tangential excision of burned tissue until capillary bleeding appears to make a good bed to be covered with grafts" split thickness grafts STG" at the same time.

• The first dressing will be in the fifth day post operative.

• In the other hand the second group will include:

  1. Patients with bad general condition or hemodynamicaly unstable at the early excision period (4-10 days post burn).
  2. Patients that refuse early surgery and give no consent for early surgery.
  3. Patients with no available donner site for early excision and grafting during the fourth day evaluation .

Enrollment: 40 estimated patients

Sex: All

Ages: 1 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients who had deep second and third degree burns.
2. patients with flame and scald burns.

Exclusion criteria

1. Patients who had only first or superficial second degree burns.
2. patients with high voltage contact electric burns and chemical burns.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Early Excision and Grafting

Experimental group

Description:

* The early excision will be done surgically within 4-10 days post burn by whatson knife by tangential excision of burned tissue until capillary bleeding appears to make a good bed to be covered with grafts" split thickness grafts STG" at the same time. * The first dressing will be in the fifth day post operative.

Treatment:

Procedure: Excision and Grafting

Dressing and Delayed Grafting

Experimental group

Description:

• Dressing will be done for the second group every other day until spontanous eschar seperation or after surgiacl debridrment of adherent eschar then for delayed grafting more than 10 days post burn.

Treatment:

Procedure: dressing then delayed grafting