Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

Shiraz University of Medical Sciences

Status and phase: Completed; Phase 2

Conditions: Contrast Induced Nephropathy

Treatments: Drug: sodium bicarbonate; Drug: Acetazolamide; Drug: normal salin

Study type: Interventional

Funder types: Other

Identifiers

NCT00634491

2438

Details and patient eligibility

About

The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy

Full description

Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.

Enrollment: 240 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patient that underwent coronary angiography

Exclusion criteria

• serum Cr. more than 3 mg/dl
• electrolyte and acid-base imbalance
• pulmonary edema
• allergy to Acetazolamide

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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240 participants in 3 patient groups

1

Active Comparator group

Description:

150 meq/l NaHco3 3cc/kg/hr one Hour before and 1cc/kg/hr 6 hour after angiography

Treatment:

Drug: sodium bicarbonate

2

Active Comparator group

Description:

Acetazolamide 250 mg + 1cc/kg/hr normal salin 6 hour before and after angiography

Treatment:

Drug: Acetazolamide

3

Active Comparator group

Description:

normal salin 1cc/kg/hr before and after angiography

Treatment:

Drug: normal salin