Comparison Between Emdogain and Amniotic Membrane as a Scaffold in Endodontic Regeneration of Immature Anterior Teeth

Al-Azhar University

Status: Active, not recruiting

Conditions: Non-vital Immature Anterior Teeth

Treatments: Other: Regenerative endodontic treatment with conventional blood clot technique.; Other: regenerative endodontic treatment with amniotic membrane; Other: regenerative endodontic treatment with emdogain.

Study type: Interventional

Funder types: Other

Identifiers

NCT07252167

Endodontic regeneration

Details and patient eligibility

About

To evaluate the clinical outcomes and cone-beam computed tomography findings of enamel matrix derivative and amniotic membrane in regenerative endodontic treatment of non-vital immature permanent anterior teeth

Full description

To evaluate the clinical outcomes and cone-beam computed tomography findings of enamel matrix derivative in comparison to amniotic membrane and MTA as a conventional group in regenerative endodontic treatment of non-vital immature permanent anterior teeth

Enrollment: 39 patients

Sex: All

Ages: 7 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

•Patients age ranges between 7 and 12 years at the time of enrolment including both genders. •Provision of informed consent by one parent or legal guardian. •At least one immature permanent anterior tooth diagnosed with pulp necrosis with or without periapical lesions. •Restorable teeth. •Compliant patient/parent. •Radiologic evidence of open apices (Teeth are considered immature when a minimum of 1 mm apical foramen width is evident)

Exclusion criteria

•Teeth with root fractures or split roots. •Presence of root resorptions. •Presence of periodontal pockets. •Developmental anomalies. •Presence of periapical radiolucency of more than 10 mm. •Tooth with class III mobility.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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39 participants in 3 patient groups

Regenerative endodontic treatment using MTA

Experimental group

Description:

Regenerative endodontic treatment with conventional blood clot technique.

Treatment:

Other: Regenerative endodontic treatment with conventional blood clot technique.

Regenerative endodontic treatment using emdogain

Experimental group

Description:

regenerative endodontic treatment with emdogain

Treatment:

Other: regenerative endodontic treatment with emdogain.

Regenerative endodontic treatment using amniotic membrane

Other group

Description:

regenerative endodontic treatment with amniotic membrane

Treatment:

Other: regenerative endodontic treatment with amniotic membrane