Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients (QT long)

Nantes University Hospital (NUH)

Status: Unknown

Conditions: Long QT Syndrome Type 1 or 2

Treatments: Other: exercise test; Other: Epinephrine test

Study type: Interventional

Funder types: Other

Identifiers

NCT01745666

RC11_0160

Details and patient eligibility

About

The aim of the study is to evaluate the best stress exam to unmask long QT in patient with KCNQ1 or KCNH2 mutation without long QT interval in rest electrocardiogram.

Full description

65 patients with KCNQ1 or KCNH2 mutation presenting QTc interval <470msec and 65 patients without KCNQ1 or KCNH2 mutation presenting QTc interval <470msec will be included.

All patients will have the 2 tests: exercise test and epinephrine test, in one half day.

At the end of the inclusions, two experts will examine examens results without knowing in which arm (mutated or not) the patient belongs.

Enrollment: 130 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients with QTc<470 msec, and with molecular analysis (KCNQ1 or KCNH2 genes) performed in order to include 65 patients with KCNQ1 or KCNH2 mutation and 65 patients without KCNQ1 or KCNH2 mutation (controls).

Exclusion criteria

• QTc interval >470msec
• Treatment interfering with cardiac repolarisation
• Under 15 years old
• Pregnant women
• Contraindication to exercise or epinephrine tests
• Patients without social coverage

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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130 participants in 2 patient groups

patients with KCNQ1 or KCNH2 mutation

Experimental group

Treatment:

Other: Epinephrine test

Other: exercise test

patients WITHOUT KCNQ1 or KCNH2 mutation (control group)

Other group

Treatment:

Other: Epinephrine test

Other: exercise test