Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy

UPECLIN HC FM Botucatu Unesp

Status: Unknown

Conditions: Hypertension, Portal; Hepatic Encephalopathy; Liver Cirrhosis

Treatments: Drug: Neomycin; Drug: Erythromycin

Study type: Interventional

Funder types: Other

Identifiers

NCT01097811

upeclin/HC/FMB-Unesp-41

Details and patient eligibility

About

Comparison between the efficacy of two different antibiotics in patients with overt hepatic encephalopathy. The study is randomized, controlled and double-blinded.

Enrollment: 20 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hepatic cirrhosis or portal hypertension
• Hepatic Encephalopathy

Exclusion criteria

• Acute liver failure
• Neuropsychiatric diseases
• Inflammatory bowel diseases
• Intestinal obstruction
• Shock
• Renal insufficiency
• Alcoholic hepatitis
• Alcohol abuse
• Antibiotic premedication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Erythromycin

Active Comparator group

Treatment:

Drug: Erythromycin

Neomycin

Active Comparator group

Treatment:

Drug: Neomycin