Comparison Between Interleukin 6 and Procalcitonin in Detecting Sepsis and Incidence of Mortality in Burn ICU Patients

Ain Shams University

Status: Enrolling

Conditions: Death; Burns; Septic Shock; Sepsis

Treatments: Diagnostic Test: Interleukin 6

Study type: Interventional

Funder types: Other

Identifiers

NCT06915974

FMASU MS 10/2024/2025

Details and patient eligibility

About

The investigators will compare the efficacy of Interleukin-6 (IL-6) as a better indicator than procalcitonin in burn patients with sepsis or septic shock regarding success of treatment and early ICU discharge.

Full description

Interleukin 6 and procalcitonin will be sampled for all patients on days 1, 3, 7, and 10.

Treatment plan will be initiated to all patients according to the burn ICU protocol.

According to the lab results, interleukin 6 and procalcitonin will guide the investigators to take decisions regarding clinical improvement and ICU stay.

Enrollment: 70 estimated patients

Sex: All

Ages: 25 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with acute burn admitted to burn ICU within 24 hours from the burn incidence.
• patients with burn percentage of 25% to 50% of total body surface area
• patients with second to third degree burns
• ASA 1 and ASA 2 patients

Exclusion criteria

• Burn percentage more than 50% or less than 25% of total body surface area
• Having autoimmune diseases
• Cancer patients
• ASA 3 and ASA 4 patients

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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70 participants in 1 patient group

Burn ICU patients

Experimental group

Description:

Interleukin 6 and procalcitonin will be sampled for all patients on days 1, 3, 7, and 10. Treatment plan will be initiated to all patients according to the burn ICU protocol.

Treatment:

Diagnostic Test: Interleukin 6