coMparison Between invAsive and Non-invasive assessmenT on Blood Pressure and Cardiac Function in HealthY Participants (MATCHY)

Tongji University

Status: Unknown

Conditions: Healthy Volunteer

Treatments: Diagnostic Test: Invasive left ventricular diastolic function assessment; Diagnostic Test: Non-Invasive left ventricular diastolic function assessment; Diagnostic Test: Non-Invasive aortic blood pressure measurement; Diagnostic Test: Invasive aortic blood pressure measurement

Study type: Observational

Funder types: Other

Identifiers

NCT03372616

MATCHY2017YZ

Details and patient eligibility

About

This is a cross-sectional cohort study which aims to compare the invasive and non-invasive assessments on aortic blood pressure and cardiac funtion in subjects without history of cardio-vascular disease. Left ventricular (LV) filling pressure, LV volume, and aortic blood pressure will be measured invasively. Non-invasive assessment includes echocardiography,aortic, and carotid blood pressure measurement.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Over or equal to 18 years old;
• Agree to participate the study and sign informed written consent;
• Any change of drugs which effect the hemodynamics during 1 month prior to enrollment;
• Proposed to perform coronary angiography and left left ventriculography in hospital;

Exclusion criteria

• Non-sinus rhythm or frequent extra systoles;
• Identified coronary artery disease via coronary angiography;
• Diagnosed pulmonary vascular or parenchymal disease;
• Hypertrophic cardiomyopathy, restrictive cardiomyopathy, or constrictive pericarditis;
• Stenosis or insufficiency of valves (moderate and above);
• Heart transplant;
• Congenital heart disease;
• Inadequate imaging or doppler parameter quality in echocardiography.

Trial design

100 participants in 1 patient group

All participants

Description:

Aortic blood pressure, LV filling pressrue, and LV volume will be measured in all participants. Meanwhile, echocardiography and non-invasive aortic blood presure measurement will be performed. Three devices will be used in non-invasive aortic blood presure measurement, including Sphygmocor (AtCor Medical, Australia), PulsePen (DiaTecne SRL, Italy), and Mobil-O-Graph (IEM, Germany). In conclusion, all participants will receive invasive and non-invasive left ventricular diastolic function assessment, together with invasive and non-invasive aortic blood pressure assessment.

Treatment:

Diagnostic Test: Invasive aortic blood pressure measurement

Diagnostic Test: Non-Invasive aortic blood pressure measurement

Diagnostic Test: Non-Invasive left ventricular diastolic function assessment

Diagnostic Test: Invasive left ventricular diastolic function assessment