Comparison Between Latanoprost , Travoprost and Tafluprost in Reducing IOP Fluctuation in POAG Patients

Kasr El Aini Hospital

Status: Completed

Conditions: Primary Open Angle Glaucoma

Treatments: Drug: Latanoprost 0.005% Ophthalmic Solution; Drug: Tafluprost Ophthalmic 0.0015% Ophthalmic Solution; Drug: Travoprost 0.004% ophthalmic solution

Study type: Observational

Funder types: Other

Identifiers

NCT04461249

411993

Details and patient eligibility

About

Elevated IOP is a key risk factor for the progression of glaucoma. IOP is subjected to diurnal fluctuation in healthy individuals and higher fluctuation in POAG . So, once-daily antiglaucoma drugs must have consistent efficacy throughout the day. Prostaglandin analogues (PGAs) have become the first-line drops for medical treatment of glaucoma worldwide. In our study, we compare between the efficacy and tolerability of Latanoprost 0.005%, Travoprost 0.004% and Tafluprost 0.0015% on diurnal IOP fluctuation in patients having POAG, IOP fluctuation was assessed before treatment , then 2 weeks and 6 weeks after. A comparable and significant reduction in IOP fluctuation occurred in the 3 groups. Side effects were mild and tolerable.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both genders aged 18 years or more.
• Newly diagnosed POAG cases having :

IOP more than 21 mmHg Open angle on gonioscopy Showing both structural and functional damage (confirmed with OCT and visual field)

Exclusion criteria

• Angle closure glaucoma.
• Secondary glaucomas.
• Advanced glaucoma likely to be uncontrolled on monotherapy or needing a low target IOP.
• History of ocular trauma, laser or intraocular surgery.
• Any other ocular disorder including uveitis and cystoid macular edema.
• Known history of allergy or sensitivity to any components of the study medications.

Trial design

60 participants in 3 patient groups

Latanoprost group

Description:

Latanoprost 0.005 % eye drops was given once by night for 3 months for newly diagnosed primary open-angle glaucoma patients.

Treatment:

Drug: Latanoprost 0.005% Ophthalmic Solution

Travoprost group

Description:

Travoprost 0.004 % eye drops was given once by night for 3 months for newly diagnosed primary open-angle glaucoma patients.

Treatment:

Drug: Travoprost 0.004% ophthalmic solution

Tafluprost group

Description:

Tafluprost 0.0015 % eye drops was given once by night for 3 months for newly diagnosed primary open-angle glaucoma patients.

Treatment:

Drug: Tafluprost Ophthalmic 0.0015% Ophthalmic Solution