Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure

Mahidol University

Status: Completed

Conditions: Respiratory Failure; on Invasive Mechanical Ventilation; ARDS

Treatments: Procedure: Limited driving pressure; Procedure: Conventional mechanical ventilation strategies

Study type: Interventional

Funder types: Other

Identifiers

NCT04035915

SI828/2016

Details and patient eligibility

About

Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure.

Full description

Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury. Limited driving pressure and low tidal volume ventilation strategies show benefits decreasing mortality in acute respiratory distress syndrome, but there are no data in simple acute respiratory failure.

To compare lung injury score (LIS, Murray score) after invasive mechanical ventilation 7 days between groups of limited driving pressure ventilation versus low tidal volume ventilation strategies.

Enrollment: 126 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 year old MICU patient
• On Invasive mechanical ventilator less than 24 hr. before randomization

Exclusion criteria

• Suspected death within 48 hr. after randomization
• patients with tracheostomy tube
• Pregnancy
• Do not attempt resuscitation order
• Patient with ECMO before randomization

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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126 participants in 2 patient groups

Limited driving pressure ventilation

Experimental group

Treatment:

Procedure: Limited driving pressure

Conventional mechanical ventilation strategies

Experimental group

Treatment:

Procedure: Conventional mechanical ventilation strategies