Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty

Thammasat University

Status and phase: Completed; Phase 4

Conditions: Blood Loss, Surgical

Treatments: Drug: Tranexamic Acid

Study type: Interventional

Funder types: Other

Identifiers

NCT03044041

OrthoTU08

Details and patient eligibility

About

The purpose of this study is to compare blood loss between using low dose (500 mg) and high dose (3 g) topical intra-articular tranexamic acid after total knee arthroplasty in double-blind RCT

Enrollment: 80 estimated patients

Sex: All

Ages: 50 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Osteoarthritic knee who underwent primary total knee arthroplasty

Exclusion criteria

• Abnormal coagulation or bleeding disorder
• Allergy to tranexamic acid
• History of thromboembolism or ischemic heart disease or cerebrovascular accident
• chronic kidney disease stage 3-4

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

80 participants in 2 patient groups

Low dose

Experimental group

Description:

single dose of intra-articular Tranexamic acid 500 miligrams

Treatment:

Drug: Tranexamic Acid

High dose

Active Comparator group

Description:

Single dose of intra-articular Tranexamic acid 3 grams

Treatment:

Drug: Tranexamic Acid