Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper

New York State Psychiatric Institute

Status and phase

Completed

Phase 2

Conditions

Marijuana Dependence

Treatments

Drug: marijuana cigarette

Drug: Marijuana blunt

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00374127

4683

Details and patient eligibility

About

The purpose of this study is to investigate whether or not marijuana blunts will produce comparable plasma THC levels as marijuana joints and if blunts will produce larger cardiovascular and subjective effects.

Full description

There has been a rapid increase in marijuana use during the 1990s, with the most recent generation often smoking marijuana in the form of 'blunts' as opposed to more traditional routes such as in pipes or in cigarette paper. A blunt is made by removing the tobacco from a cigar and replacing it with marijuana (Golub and Johnson, 1999). The cigar wrapper contains tobacco and nicotine, which may interact with the cardiovascular and subjective effects of the marijuana to produce a different set of effects and risks than cigarette paper. Anecdotally, marijuana smokers report that blunts are more potent than joints, yet there have been no controlled studies addressing whether blunts enhance the subjective-effects and health-related consequences of marijuana use. We are proposing to do a within-subject, placebo-controlled study directly comparing the cardiovascular, subjective and pharmacokinetic effects of marijuana smoked in blunts compared to identical quantities of marijuana smoked in cigarette paper. Research volunteers will be current blunt smokers. Each will participate in six, 4-hour outpatient sessions. After baseline data have been collected (heart rate, blood pressure, mood scales, exhaled carbon monoxide, plasma THC and nicotine levels), participants will take 3 puffs, 5 seconds in duration, from a NIDA marijuana cigarette containing 0.0, 1.8 and 3.6% THC or from a blunt containing an equivalent quantity and strength of marijuana. Participants will be blind to the type of marijuana cigarette smoked. We will measure plasma THC and nicotine, subjective mood ratings, and heart rate and blood pressure repeatedly over the course of 180 minutes following smoking. This study is the first controlled investigation of the consequences of this new method of marijuana smoking; the data obtained may be useful in guiding future development of marijuana pharmacotherapy.

Enrollment

35 patients

Sex

All

Ages

21 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Current blunt marijuana use (minimum of twice/week) drug screen
21-45 years of age
Practicing an effective form of birth control (condoms, diaphragm, birth control pill, IUD)

Exclusion criteria

Current, repeated illicit drug use(excluding marijuana)
Heavy cigarette use (> 10 cigarettes/day)
Presence of significant medical illness (e.g., diabetes, cardiovascular disease, hypertension)
Laboratory tests outside normal limits that are clinically unacceptable to the study physician (BP > 140/90; hematocrit < 34 for women, < 36 for men)
Significant adverse reaction to marijuana
Current parole or probation
Pregnancy or current lactation
History of significant violent behavior
Major current Axis I psychopathology(e.g., mood disorder with functional impairment or suicide risk, anxiety disorder, schizophrenia)
History of heart disease
Current use of any over-the-counter or prescription