Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty

Hillel Yaffe Medical Center

Status: Completed

Conditions: Pain, Postoperative; Analgesia

Treatments: Drug: Bupivacaine; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT02253784

14-XX-HYMC

Details and patient eligibility

About

The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block in total knee arthroplasty. The aim of this study is to determine whether this is a systemic or local effect.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pre-surgical total knee arthroplasty patients

Exclusion criteria

• Skin infection near block site
• Allergy to local anesthetics
• Peripheral neuropathy
• Proven opioid dependency
• Coagulopathy
• Dementia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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90 participants in 3 patient groups

Group I (ISB-P)

Active Comparator group

Description:

Four nerve blocks with perineural injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml

Treatment:

Drug: Dexamethasone

Drug: Bupivacaine

Group II (ISB-S)

Active Comparator group

Description:

Four nerve blocks with systemic injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml

Treatment:

Drug: Dexamethasone

Drug: Bupivacaine

Group III (ISB-C)

Active Comparator group

Description:

Four nerve blocks without dexamethasone

Treatment:

Drug: Bupivacaine