Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia

Minia University

Status and phase: Enrolling; Phase 2; Phase 1

Conditions: Functional Endoscopic Sinus Surgery

Treatments: Other: surgeon satisfaction; Drug: Pregabalin 150mg; Drug: Magnesium Sulfate; Drug: Nitroglycerin

Study type: Interventional

Funder types: Other

Identifiers

NCT05442931

55:2021

Details and patient eligibility

About

Comparison between pregabalin and magnesium sulfate in hypotensive anaethesia

Full description

compare the effect of a single-dose 150 mg oral pregabalin and 2 grams intravenous magnesium sulfate given 30 minutes before induction of anesthesia on the total nitroglycerine used in patients undergoing functional endoscopic sinus surgery

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA: class 1 or 2
• Sex: male and female
• Age: from 18 to 70 years
• Patients scheduled for functional endoscopic sinus surgery

Exclusion criteria

• Patient on diuretics, corticosteroid, pregabalin
• Patients with a history of allergy to the study drug
• Pregnancy or breastfeeding women Patients with hypertension, cardiac, renal endocrinal diseases
• uncooperative patients (cant does not administer oral tablet)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 3 patient groups

Pregabaline

Experimental group

Description:

Preoperative oral dose of pregabalin for control blood pressure and decrease dose of nitroglycerine consumption

Treatment:

Drug: Pregabalin 150mg

Magnesium sulfate

Experimental group

Description:

Preoperative intravenous dose for control blood pressure and heart rate

Treatment:

Drug: Magnesium Sulfate

Nitroglycrine

Experimental group

Description:

Measuring the total dose of nitroglycerine used, using a syringe pump

Treatment:

Drug: Nitroglycerin

Other: surgeon satisfaction