Comparison Between Remifentanil Target-controlled Infusion and Dexmedetomidine Bolus Administration for Smooth Emergence From General Sevoflurane Anesthesia

Yonsei University

Status: Completed

Conditions: Thyroid Neoplasm

Treatments: Drug: Normal Saline; Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01617694

4-2011-0181

Details and patient eligibility

About

Remifentanil target-controlled infusion and dexmedetomidine single-dose administration are known to reduce airway response and haemodynamic stimulation during anaesthetic recovery. The investigators will compare the effects of two drugs on prevention of cough during emergence from general sevoflurane anaesthesia.

Enrollment: 65 patients

Sex: Female

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female patient,
• aged 20-60 yr,
• ASA physical status 1-2,
• patients undergoing elective thyroidectomy under general anesthesia

Exclusion criteria

• sighs of difficult airway,
• history of respiratory disease or chronic cough,
• cardiovascular disease,
• pregnant or breast-feeding woman.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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65 participants in 2 patient groups

group R

Experimental group

Description:

continuation of remifentanil target controlled infusion (TCI) at effect-site concentration of 2 ng/ml during anesthetic recovery until extubation.

Treatment:

Drug: dexmedetomidine

Drug: Normal Saline

group D

Active Comparator group

Description:

remifentanil TCI discontinuation and dexmedetomidine 0.5 mg/kg intravenous injection before 10 min of the end of surgery

Treatment:

Drug: dexmedetomidine

Drug: Normal Saline