Comparison Between spIgE and Skin Prick Test of Local and Imported Aeroallergens

Mahidol University

Status: Completed

Conditions: Immediate Hypersensitivity

Treatments: Other: specific IgE measurement; Procedure: Skin prick test

Study type: Interventional

Funder types: Other

Identifiers

NCT02561390

Si521/2013

Details and patient eligibility

About

The prevalence of Allergic rhinitis(AR) and asthma was increased world wide. In 1998, ISAAC found that prevalence of AR and asthma inThailand was in moderately high group.

Tests for immediated reaction SPT and spIgE, were used for evaluated sensitization of allergen in patient. They guided the investigators for proper management as well as patient education. Clinician will use the result for choose allergen in case that might need immunotherapy.

SPT is safe and more economic for patient. Specific IgE has an advantage in patient who cannot withhold antihistamine prior SPT. In United state had a trial of result between SPT and spIgE for cockroach, cat, house dust mite and mold. It showed the correlation between two tests. In Thailand, the investigators haven't had data about it yet.

Full description

SPT and specific IgE for allergens is necessary for allergen avoidance and specific immunotherapy. To have local allergen extracts will help the patients to easier get the appropriate management

Enrollment: 84 patients

Sex: All

Ages: 10 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with controlled Asthma and/or AR (mild to moderate severity) who were diagnosed in Allergy clinic and ENT clinic, Siriraj hospital
• SPT positve one of American Cockroach, House dust mite, cat, dog and mold.
• Patient were consented to trial.

Exclusion criteria

• Chronic disease such as heart disease, liver, renal and severe sepsis
• History of anaphylaxis
• Skin rash
• Pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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84 participants in 2 patient groups

Skin prick test with aeroallergens

Experimental group

Description:

Mean wheal diameters of SPT with commercial and local American coakroach, house dust mite, cat, dog and mold

Treatment:

Procedure: Skin prick test

Other: specific IgE measurement

specific IgE measurement

Experimental group

Description:

specific IgE levels of commercial and local American coakroach, house dust mite, cat, dog and mold

Treatment:

Procedure: Skin prick test

Other: specific IgE measurement