Comparison Between Tamsulosin and Tadalafil in Management of Benign Prostatic Hyperplasia Long Term Study

Mansoura University

Status and phase

Completed

Phase 4

Conditions

BPH

Treatments

Drug: Tadalafil

Drug: Tamsulosin

Study type

Interventional

Funder types

Other

Identifiers

NCT05818670

tadalafil vs tamsulosin in bph

Details and patient eligibility

About

Comparison between tamsulosin and Tadalafil in management of benign prostatic hyperplasia A Randomised Trial

Full description

Assessment of the discontinuation rate of tamsulosin and tadalafil after 12 months follow up either and evaluate the changes in urinary parameters and sexual parameters in patients with lower urinary tract symptoms due to BPH concomitant with erectile dysfunction. We tried to overcome the limitations of the previous studies by designing a prospective randomized controlled trial as the present study is the first randomized controlled trial that evaluate the safety, discontinuation rate and efficacy of tadalafil compared with tamsulosin for long term follow up (12 months).

Enrollment

160 patients

Sex

Male

Ages

50+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

patients with Lower Urinary Tract Symptoms
married and sexually active
age more than 50 years
IPSS more than 12
Q max less than 15 ml/s
Post voiding residual less than 150 ml

Exclusion criteria

prostatic adenocarcinoma
cardiac patients on nitrates, patient with unstable angina or recent history of myocardial infarction
vesical stones
active Urinary Tract Infection
patient refused participation in the study