Comparison Between Ticagrelor Versus Very Low Dose Rivaroxaban With Clopidogrel

Seoul National University

Status: Completed

Conditions: Unstable Angina; Acute Coronary Syndrome; Acute Myocardial Infarction

Study type: Observational

Funder types: Other

Identifiers

NCT03481257

06-2017-086

Details and patient eligibility

About

A total of 50 participants diagnosed with ACS (group A ticagrelor 180mg/d, n=25), group B (clopidogrel 75mg + rivaroxaban 5mg/ d, n=25)) were consecutively enrolled and treated with study drugs on top of aspirin (100mg/d) for 1 month. VerifyNow® and Global thrombosis test were performed at day 2 and 1 month after administration of study drugs. The investigators compared aspirin reaction unit (ARU) and P2Y12 reaction unit (PRU), occlusion time (OT) which reflects shear stress-induced thrombotic activity, and lysis time (LT) which showed endogenous lytic activity between the two strategies at both time points.

Enrollment: 56 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who were diagnosed with acute coronary syndrome and underwent percutaneous coronary intervention

Exclusion criteria

• Patients administered with glycoprotein IIb/IIIa inhibitiors
• Patients with atrial fibrillation
• Patients with high risk of bleeding at the physician's discretion
• Patients with renal impairment (estimated GFR <30ml/min)

Trial design

56 participants in 2 patient groups

Ticagrelor

Description:

ACS patients treated with aspirin (100mg/d) and ticagrelor (90mg bid)

Clopidogrel + very low dose rivaroxaban

Description:

ACS patients treated with aspirin (100mg/d), clopidogrel(75mg/d) and very low dose rivaroxaban (2.5mg bid)