Comparison Between Two Fertility Protocols in Obese Polycystic Ovary Syndrome Patients

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Obese; Infertility; Polycystic Ovary Syndrome

Treatments: Procedure: IVM (In Vitro Maturation) Treatment; Procedure: IVF (In Vitro Fertilization) Antagonist Protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT01473459

0078-11-HYMC

Details and patient eligibility

About

The purpose of this study is to compare two fertility protocols in obese women with Polycystic Ovarian Syndrome who are candidates for In Vitro Fertilization (IVF). These protocols carry less risk of ovarian hyperstimulation syndrome which these women may experience.

Full description

The purpose of this study is to compare two fertility protocols in obese women with Polycystic Ovarian Syndrome who are candidates for In Vitro Fertilization (IVF). These protocols carry less risk of ovarian hyperstimulation syndrome which these women may experience.The patients in the IVM group will not be exposeD to gonadotropin treatment for controlled ovarian hyperstimulation. In the antagonist group we will use GnRH agonist to induce ovulation which may reduce the risk for ovarian hyperstimulation.

Enrollment: 40 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• BMI > 30
• PCOS
• Failure of COH treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

IVM Treatment

Active Comparator group

Treatment:

Procedure: IVM (In Vitro Maturation) Treatment

Antagonist Protocol

Active Comparator group

Treatment:

Procedure: IVF (In Vitro Fertilization) Antagonist Protocol