Comparison Between Uterine Artery Doppler and Placental Vascular Indices in Prediction of Preeclampsia

National Research Centre, Egypt

Status: Unknown

Conditions: Pre-Eclampsia

Treatments: Device: ultrasound machine

Study type: Observational

Funder types: Other

Identifiers

NCT03838887

placental vascular indices

Details and patient eligibility

About

• Preeclampsia is a multisystem disorder that can cause considerable maternal and fetal morbidity and mortality. Late preeclampsia (with delivery >34 weeks) is more frequent and less serious than early preeclampsia (with delivery <34 weeks). Poor early placentation has been especially associated with early disease. Early identification of women at risk of preeclampsia is currently a crucial aim of antenatal care since they may benefit from prophylactic treatment and increased surveillance.

Full description

• The introduction of three-dimensional (3D) ultrasound techniques, with the option of calculating placental volume and measuring vascular indices, has created an excellent opportunity to study early changes in the uteroplacental circulation space, which includes the maternal spiral arteries and the intervillous space. This technology may allow a more direct evaluation of the abnormal placentation process thought to herald the development of preeclampsia.
• The aim of this study was to assess the usefulness of placental volume and 3D vascular indices as reliable predictors of early preeclampsia in comparison to uterine artery Doppler

Enrollment: 100 estimated patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• A. Control group: Pregnant women:

  1. Age between 18-35 years
  2. Parity: primigravidas and multiparas.
  3. Have no history of preeclampsia or eclampsia.
  4. Have no history of chronic hypertension.
  5. Not diabetic.
  6. Not have antiphospholipid syndrome.
  7. Not have autoimmune disease such as SLE.

B. High risk group: Pregnant women with:

1. History of preeclampsia -Eclapmsia
2. Chronic hypertension
3. Diabetic
4. Antiphospholipid syndrome.
5. Autoimmune syndrome such as SLE.

Exclusion criteria

• • Smoking

  • Dichorionic placentae
  • Fetal anomaly
  • Uterine fibroid at the site of placental implantation
  • Subchorionic hematoma

Trial design

100 participants in 2 patient groups

control group

Description:

Pregnant women: 1. Age between 18-35 years 2. Parity: primigravidas and multiparas. 3. Have no history of preeclampsia or eclampsia. 4. Have no history of chronic hypertension. 5. Not diabetic. 6. Not have antiphospholipid syndrome. 7. Not have autoimmune disease such as SLE

Treatment:

Device: ultrasound machine

High risk group

Description:

Pregnant women with: 1. History of preeclampsia -Eclapmsia 2. Chronic hypertension 3. Diabetic 4. Antiphospholipid syndrome. 5. Autoimmune syndrome such as SLE.

Treatment:

Device: ultrasound machine