Comparison Between Volume Controlled Ventilation and Pressure Controlled Ventilation

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Reduced Lung Compliance.; Laparoscopy.; Obesity; Anesthesia.

Treatments: Procedure: Mechanical Ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT00224653

P040405

PS040405

Details and patient eligibility

About

To assess the potential benefits on mechanical ventilation plateau pressure of pressure controlled mode versus volume controlled mode for laparoscopic bariatric surgery in obese patients (BMI > 35). High plateau pressures encountered in obese patients due to their reduced pulmonary compliance could be lowered using pressure controlled mechanical ventilation.

Full description

All patients are over 18 years old and give their inform consent after approval of the study protocol by an ethic committee. Anesthesia is standardized and all patients are intubated. Precise protocols are used to perform pressure and volume controlled ventilation in order to regulate End-Tidal CO2 between 33 and 35 mmHg. Primary goal is comparison of plateau pressures observed in the 2 ventilation modes after 45 minutes of pneumoperitoneum. Secondary goals are : comparison of PaO2 and PaCO2 after 45 minutes of pneumoperitoneum and after 2 hours spent in post-anesthesia care unit ; comparison of total respiratory resistances and peak flow generated between the 2 modes.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients are over 18 years old and give their inform consent
• morbid obesity(BMI>35)
• laparoscopic bariatric surgery

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind