Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 mg for Post Lobectomy Analgesia (pain)

Mahidol University

Status and phase: Completed; Phase 4

Conditions: Lung Diseases; Solitary Mass

Treatments: Drug: spinal morphine 0.3 mg; Drug: spinal morphine 0.2 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT01236495

si578/2010

Details and patient eligibility

About

The purpose of the study is to evaluate the amount of total pethidine requirement during the 48 hour postoperative period after receiving spinal morphine 0.2 and 0.3 mg.

Full description

Thoracotomy causes severe pain to the patients. Continuous thoracic epidural is a gold standard for postoperative pain. However, it needs skill. There are many alternatives such as spinal morphine, intercostal nerve block, cryoalangesia or interpleural block.

Enrollment: 40 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 year and < 70 year
• Patient ASA physical status I-III.
• Scheduled for thoracotomy with lobectomy.
• Can operate a patient-controlled analgesia (PCA) device.

Exclusion criteria

• Known hypersensitivity to morphine or pethidine
• History of bleeding tendency.
• Known case of infection at the back
• Patient refuse for spinal anesthesia
• History of cerebrovascular disease.
• Scheduled for video-assisted thoracoscopic lobectomy.
• Need mechanical ventilatory support during postoperative period

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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40 participants in 2 patient groups

spinal morphine 0.2 mg

Experimental group

Description:

spinal morphine 0.2 mg

Treatment:

Drug: spinal morphine 0.2 mg

spinal morphine 0.3 mg

Active Comparator group

Description:

spinal morphine 0.3 mg

Treatment:

Drug: spinal morphine 0.3 mg