Comparison of 0.375% Ropivacaine and 0.25% Levobupivacaine for Infraclavicular Brachial Plexus Block

A

Asan Medical Center

Status and phase

Completed
Phase 4

Conditions

Regional Anesthesia

Treatments

Drug: Levobupivacaine solution
Drug: Ropivacaine solution

Study type

Interventional

Funder types

Other

Identifiers

NCT03679897
2018-1117

Details and patient eligibility

About

Infraclavicular brachial plexus block has been used more frequently with the development of high-resolution ultrasound. Compared with peripheral nerve block using landmark technique or nerve stimulator technique, ultrasound-guided peripheral nerve block decreases the required dose of local anesthetics. As the dose of the drug used decreases, the systemic toxic effects of local anesthetics are reduced. However, the decreased dose of the drugs might have influence on the onset time of local anesthetics. Thus, the investigator aimed to evaluated the onset time of the two equipotent local anesthetics, 0.375% ropivacaine and 0.25% levobupivacaine.

Enrollment

46 patients

Sex

All

Ages

19 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • American Society of Anesthesiologists physical status 1-3
  • Patients undergoing upper extremity surgery with infraclavicular brachial plexus block

Exclusion criteria

  • Patients who do not agree to participate in clinical trial
  • Patients presenting with neurological deficits of the upper arm, severe coagulopathy, chronic renal failure, cardiopulmonary compromise, cerebral vascular disease, hypersensitivity to hyaluronidase or local anesthetics or local infection at the site of the infraclavicular block, pregnancy

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

46 participants in 2 patient groups

Ropivacaine group
Experimental group
Description:
BPB with 0.375% ropivacaine solution
Treatment:
Drug: Ropivacaine solution
Levobupivacaine group
Active Comparator group
Description:
BPB with 0.25% levobupivacaine solution
Treatment:
Drug: Levobupivacaine solution

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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