Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma

Ishtiaq Ahmed

Status and phase: Completed; Phase 2

Conditions: Melasma

Treatments: Drug: Metformin and Nicotinamide vs Kligman Formula

Study type: Interventional

Funder types: Other

Identifiers

NCT05790577

PakEmiratesMH2

Details and patient eligibility

About

Comparison of 30% Metformin and 2% Nicotinamide lotion with kligman formula in the treatment of Melasma

Full description

A comparative study to evaluate Efficacy and tolerability of new lotion in the treatment of Melasma.

Enrollment: 88 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 18-50
• No systemic therapy
• All Co-morbids

Exclusion criteria

• Pregnancy
• Age >50
• Taking oral treatment for melasma

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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88 participants in 2 patient groups

Metformin 30% and 2% Nicotinamispde

Active Comparator group

Description:

Metformin 30% plus Nicotinamide 2% in the reatment of Melasma

Treatment:

Drug: Metformin and Nicotinamide vs Kligman Formula

Kligman formula

Active Comparator group

Description:

Kligman formula in the treatment of Melasma

Treatment:

Drug: Metformin and Nicotinamide vs Kligman Formula