Comparison of 5% Nacl and 10% NaHCO3 As Contrast Agents for Lung Perfusion with EIT

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: ARDS (Acute Respiratory Distress Syndrome)

Treatments: Other: Injection of hypertonic saline; Other: Injection of 5% NaHCO3

Study type: Interventional

Funder types: Other

Identifiers

NCT06868810

EIT contrast agent

Details and patient eligibility

About

Electrical impedance tomography (EIT) has enabled the bedside monitoring of lung perfusion measurement through the indicator-based contrast method. Currently, hypertonic sodium chloride is the most commonly used contrast agent for lung perfusion evaluation by EIT. However, concerns may be raised regarding the potential risks of hyperchloremia and possible acute kidney injury associated with the use of hypertonic NaCl. Recently, two experimental studies found sodium bicarbonate (NaHCO3) might be an alternative to hypertonic sodium chloride in lung perfusion assessment by EIT. However, whether NaHCO3 results in acceptable bias is unknown in critically ill patients. This clinical study aimed to further investigate the correlation and agreement of lung perfusion and Ventilation/perfusion (V/Q) match by EIT contrast method between two contrast indicators (5%NaHCO3 vs. 10% NaCl) in critically ill patients with respiratory failure.

Enrollment: 16 patients

Sex: All

Ages: 18 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• In need of lung perfusion assessment due to clinical condition
• With central venous catheter

Exclusion criteria

• contraindications to the use of EIT (automatic implantable cardioverter defibrillator, chest wounds limiting electrode belt placement, implantable pumps, etc.)
• severe hyperchloremia (>155 mmol/L)
• unable to tolerate breath-hold maneuver
• pregnant or breastfeeding females

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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16 participants in 2 patient groups

NaCl

Experimental group

Description:

First, perform the EIT contrast method with 10% NaCl. After a 10-minute washout period, perform the EIT contrast method with 5% NaHCO3.

Treatment:

Other: Injection of 5% NaHCO3

Other: Injection of hypertonic saline

NaHCO3

Other group

Description:

First, perform the EIT contrast method with 5% NaHCO3. After a 10-minute washout period, perform the EIT contrast method with 10% NaCl.

Treatment:

Other: Injection of 5% NaHCO3

Other: Injection of hypertonic saline