Comparison of A-PRF vs Bone Wax in Hemostasis, Pain Relief and Healing Following Exodontia

Altamash Institute of Dental Medicine

Status: Enrolling

Conditions: Post-Extraction Socket Healing; Post-Extraction Socket Pain Relief; Post-Extraction Socket Hemostasis

Treatments: Biological: A-PRF; Combination Product: Bone-wax

Study type: Interventional

Funder types: Other

Identifiers

NCT05744726

F.2-81/2022-GENL/338/JPMC

Details and patient eligibility

About

The goal of this clinical trial is to compare the pain relief and healing effect of A-PRF and Bone-wax in patients having mandibular tooth-extractions. The main question[s] it aims to answer are:

In the perspective of improvement in pain and healing;

• Does A-PRF performs better than control group?
• Does Bone-wax performs better than control group?
• Healing index and Pain scale score Comparison of A-PRF and Bone-wax; if one is better than the other? Participants will be asked to give resoponse to a post-operative symptom severiety (PoSSe) scale. An investigator will score the patient's extraction for hemostasis and on healing index [describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items]. If there is a comparison group: Researchers will compare [insert groups] to see if [insert effects].

Enrollment: 129 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All patients who need extraction of mandibular posterior teeth
• Overall, systemically healthy individuals (Established based on history, i.e., patients who do not take medicine for any systemic condition).
• INR within normal range.

Exclusion criteria

• Patients with a diagnosed systemic condition.
• Patients who are immunocompromised.
• Patients who are unwilling to participate or withdraw from the study.
• Patients who fail to report on the seventh and twenty-first post-extraction day.
• Patients with physical or mental impairments who need assistance in taking their medications.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

129 participants in 3 patient groups

A-PRF

Experimental group

Description:

Advance Platelet-Rich Fibrin

Treatment:

Biological: A-PRF

Bone-wax

Active Comparator group

Treatment:

Combination Product: Bone-wax

Conventional Dental Extraction protocol

No Intervention group

Description:

Control Group