Comparison of a Prophylactic Intraligamentary Injection of Piroxicam Versus Mepecaine of Post-endodontic Pain

Cairo University (CU)

Status: Unknown

Conditions: Pulpitis - Irreversible

Treatments: Procedure: Intraligamentary mepevacaine; Procedure: intraligamentary injection piroxicam

Study type: Interventional

Funder types: Other

Identifiers

NCT03006107

piroxicam _ Mepecaine

Details and patient eligibility

About

to evaluate the effect of a single intraligamentary injection of piroxicam on postoperative pain associated with endodontic procedures.

Full description

The pain after endodontic treatment is commonly severe in the first 24 hours after treatment, then it will reduce gradually until commonly disappearing after 7-10 days in most cases. Since piroxicam has a half-life of 50 hours in the plasma, it will be effective in controlling the most intense pain which occurs after endodontic treatment It appears that optimal clinical benefits can be achieved by administering drugs such as local anesthetics and NSAIDs before the onset of postoperative pain. Administering these drugs before a surgical or an endodontic procedure may be of benefit for longer procedures or for minimizing peripheral sensitization, which is a result of the cascade of inflammatory mediators that are released by tissue injury and fuel the subsequent inflammatory process

Enrollment: 26 estimated patients

Sex: All

Ages: 25 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • Medically free patients

  • Patient's age between 25-50 years.
  • Molar or premolar teeth diagnosed clinically and radiographically with irreversible pulpitis and symptomatic apical periodontitis.
  • Positive patient's acceptance for participation in the study.
  • Sex include both male and female.
  • Patients who can understand Numerical Rating Scale (NRS)
  • Patients able to sign informed consent.

Exclusion criteria

• • Pregnancy or lactation in female patients

  • Medically compromised patients.
  • Patient with multiple teeth that required endodontic treatment to eliminate the possibility of pain referral.
  • Patient with fracture or mobile or mutilated teeth.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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26 participants in 2 patient groups

intraligamentary injection of piroxicam

Experimental group

Description:

intraligamentary injection Piroxicam is another NSAID that which has the ability for the treatment of pain, fever and inflammation in the body , has a half-life of 50h in the plasma , oral piroxicam reaches a peak concentration in the plasma within 2 to 4 hours . The needle will be placed in the gingival sulcus at a 30- degree angle to the long axis of the tooth then apical pressure is applied until the needle wedged into the periodontal ligament between the tooth and the alveolar crest of the bone

Treatment:

Procedure: intraligamentary injection piroxicam

Intraligamentary mepevacaine

Active Comparator group

Description:

mepevacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to brain . It is also used as an anesthetic for dental procedures.

Treatment:

Procedure: Intraligamentary mepevacaine