Comparison of a Water-soluble Topical Antimicrobial to Silver Sulfadiazine in Partial Thickness Burns

University of Virginia

Status and phase: Completed; Phase 4

Conditions: Burn

Treatments: Drug: silver sulfadiazine; Drug: water-soluble therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01926392

15603

Details and patient eligibility

About

Partial thickness burns are a common, painful injury requiring a great deal of resources in their care. Silver sulfadizine is a commonly-used topical antimicrobial, but is difficult to remove due to its lipid base. We are comparing a water-based topical antimicrobial therapy to silver sulfadiazine and hypothesize that the water-based therapy is superior in terms of pain control and resources required to deliver care.

Enrollment: 8 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult inpatients with partial thickness burns

Exclusion criteria

• superficial or full thickness burns, facial burns, intubated or sedated, pediatric

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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8 participants in 2 patient groups

water-soluble therapy

Experimental group

Description:

The patient acted as their own control and the experimental and comparison arms (water-soluble therapy and silver sulfadiazine) were alternated on a daily basis

Treatment:

Drug: silver sulfadiazine

Drug: water-soluble therapy

silver sulfadiazine

Active Comparator group

Description:

The patient acted as their own control and the experimental and comparison arms (water-soluble therapy and silver sulfadiazine) were alternated on a daily basis

Treatment:

Drug: silver sulfadiazine

Drug: water-soluble therapy