Comparison of ACT Between Hemochron Jr and ACT Plus

Hallym University

Status: Completed

Conditions: Cardiac Disease

Treatments: Device: ACT Plus; Device: Hemochron

Study type: Interventional

Funder types: Other

Identifiers

NCT02484157

2012-I0814

Details and patient eligibility

About

This study aimed to compare 2 activated clotting time analysers (Hemochron Jr vs. ACT Plus).

Full description

Measurement of activated clotting time (ACT) is a standard method for anticoagulation monitoring. Especially in cardiac surgery, heparin is usually used as anticoagulant and protamine is used to reverse anticoagulation effect at the end of surgery. ACT method defines the time until a clot is formed in a test tube after triggering of internal pathway coagulation using blood activating agents (eg. kaolin).

Acute normovolemic hemodilution (ANH) consists of withdrawing patient's blood volume early in the operative period and concurrent infusion of crystalloid or colloid to maintain intravascular volume, and is used in cardiac surgery. ANH is known to affect hemostasis in some studies.

Assuming that accurate monitoring of coagulation therapy is important to prevent both thrombotic and hemorrhagic complications, we compared ACT results from 2 analysers (Hemochron Jr and ACT Plus) in patients undergoing cardiac surgery using ANH.

Enrollment: 26 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent cardiac surgery with heparin administration.

Exclusion criteria

• Preoperative hemoglobin under 11g/dL
• Weight under 40kg
• Preoperative coagulopathy

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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26 participants in 1 patient group

Patient

Experimental group

Description:

Patients were checked activated coagulation time by both Hemochron Jr and ACT Plus during cardiac surgery with heparin administration.

Treatment:

Device: Hemochron

Device: ACT Plus