Comparison of Adding EMEND to PONV/PDNV Treatment Regimen

University of Nebraska

Status: Withdrawn

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: aprepitant

Study type: Interventional

Funder types: Other

Identifiers

NCT01186029

0359-09-FB

Details and patient eligibility

About

This study is looking at whether the addition of Aprepitant (Emend), an antiemetic, will provide added efficacy if added to 2 drugs that are already used as a standard of care for post-operative nausea and vomiting and post-discharge nausea and vomiting.

Full description

This study is looking at whether the addition of a fairly new drug for the treatment of post-operative nausea and vomiting (PONV) and post-discharge nausea and vomiting (PDNV) will provide added efficacy if added to 2 drugs that are already used as a standard of care for PONV and PDNV.

The patients that will be looked at will be deemed at higher risk for PONV and PDNV based on the procedure they are having done and/or on patient risk factors.

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with at least 2 of the common risk factors for PONV/PDNV; patients having a procedure deemed at high risk for PONV/PDNV

Exclusion criteria

• patients under 19 years of age; pregnant and breast-feeding patients

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups

EMEND Added to the Treatment Regimen for Post-Discharge and Post-Operative Nausea and Vomiting

Active Comparator group

Description:

The addition of Aprepitant (Emend), an antiemetic, to 2 drugs that are already used as a standard of care for post-operative nausea and vomiting and post-discharge nausea and vomiting.

Treatment:

Drug: aprepitant

Standard Treatment Regimen for Post-Discharge and Post-Operative Nausea and Vomiting

No Intervention group

Description:

No addition of Aprepitant (Emend), an antiemetic, to 2 drugs that are already used as a standard of care for post-operative nausea and vomiting and post-discharge nausea and vomiting.