Comparison of Analgesic Consumption Between Perioperative ıv Dexamethasone and Added to Femoral Block

TC Erciyes University

Status and phase: Unknown; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: serum physiologic; Drug: iv dexamethasone; Drug: femoral dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT02090790

2013/400

Details and patient eligibility

About

the aim of this study was to investigate compare the effect of peroperative intravenous single dose dexamethasone and the addition of dexamethasone to femoral nerve block on postoperative analgesic consumption and patient comfort in unilateral total knee arthroplasty patients

Full description

Total knee arthroplasty leads to severe postoperative pain. for postoperative pain control after total knee arthroplasty oral -intramuscular opioids ,patient controlled analgesia intravenous or epidural opioids, single -continuous femoral nerve block involving techniques are used.

Dexamethasone is a glucocorticoid of high potency and frequently used perioperative.Dexamethasone to the local anaesthetic solution administered trough in femoral nerve blocks significantly prolonged the analgesic effect of the local anaesthetics used on this blocks.If the analgesic efficacy of systemic treatment with dexamethasone is similar with the use of perineural wich is the safest way should be preferred for systemic use.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• between 18-65 age
• knee arthroplasty
• no known allergies to drugs
• ASA 1-2 patients

Exclusion criteria

• history of diabetes
• history of chronic pain treatment
• pregnancy
• severe bronchopulmonary disease
• systemic opioid and steroid use

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 3 patient groups, including a placebo group

iv dexamethasone

Active Comparator group

Description:

perioperative 2ml 8 mg ıv dexamethasone

Treatment:

Drug: iv dexamethasone

femoral dexamethasone

Active Comparator group

Description:

femoral block was performed postoperative 30 ml 0,5 % bupivacaine added 2 ml 8 mg dexamethasone

Treatment:

Drug: femoral dexamethasone

serum physiologic

Placebo Comparator group

Treatment:

Drug: serum physiologic