Comparison of Analgesic Effect of Volatile Anesthetics

Kangbuk Samsung Hospital

Status and phase

Completed

Phase 3

Conditions

Anesthesia

Treatments

Drug: Desflurane

Drug: Sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT02830243

2016-05-058

Details and patient eligibility

About

The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index.

Full description

Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different bispectral index values. However, the difference between analgesic effects of volatile anesthetics have not yet been investigated. The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index-guided remifentanil infusion.

Enrollment

90 patients

Sex

All

Ages

19 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients undergoing balanced general anesthesia using volatile anesthetics and remifentanil
patients with american society of anesthesiologist physical status I, II
patients aged 19-65 years
patients obtaining written informed consent

Exclusion criteria

patients with a history of any psychiatric or neurological disease
patients who had received any medication affecting the central nervous system
patients who had received medication affecting the sympathetic or parasympathetic nervous systems
patients undergoing tracheal intubation for airway management
pregnant women