Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants

Altamash Institute of Dental Medicine

Status and phase: Completed; Phase 2

Conditions: Irreversible Pulpitis

Treatments: Drug: Polyhexamethylene biguanide; Drug: Sodium Hypochlorite

Study type: Interventional

Funder types: Other

Identifiers

NCT05306431

Root canal Irrigiant

Details and patient eligibility

About

The aim of this randomized clinical trial is to compare the antibacterial effects of sodium hypochlorite (NaOCl) and Polyhexamethylene biguanide during root canal treatment .

Full description

This study will compare the antibacterial effectiveness of sodium hypochlorite and PHMB, to find out whether PHMB can be used as a substitute to NaOCL. Polyhexamethylene biguanide (PHMB), is a disinfectant solution having a broad spectrum of antimicrobial activity and is investigated as an endodontic irrigant. It is non-corrosive, non-toxic and acts by disrupting cell membrane integrity.

Enrollment: 60 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • Patients aged 18 to 50 years

  • Both male and female patients
  • Periodontally healthy teeth as determined by Periodontal Probing
  • Patients with non-vital necrotic pulps as determined by Cold Test
  • Patients with acute apical periodontitis determined by history and clinical examination
  • Clinical Findings:

Visual: Carious tooth decay Occlusion: Hyperocclusion Pulp vitality test: Negative Periapical radiograph: Caries involving pulp space and PDL widening Percussion Test: Positive Palpation Test: Negative

• Single rooted teeth as determined radiographically

Exclusion criteria

• • Multirooted teeth

  • Teeth undergoing Re-endo treatments
  • Teeth with root fractures and/ non restorable determined by clinical and radiographic examination
  • Patients receiving antibiotic treatment in the past 3 months determined by history
  • Patient with Diabetes determined by history
  • Patient with history of smoking

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Polyhexamethylene biguanide

Experimental group

Description:

Polyhexamethylene biguanide (PHMB), is a disinfectant solution having a broad spectrum of antimicrobial activity and is investigated as an endodontic irrigant. It is non-corrosive, non-toxic and acts by disrupting cell membrane integrity. PHMB 0.2% has been recently used as a root canal irrigant in vitro and has shown promising results of antimicrobial effectiveness of \> 99.9% for both PHMB and Sodium hypochlorite

Treatment:

Drug: Polyhexamethylene biguanide

Sodium Hypochloride

Experimental group

Description:

A number of irrigant solution has thus been proposed to serve the purpose, the most popular being sodium hypochlorite (NaOCl) because of its excellent antimicrobial activity but also the ability to dissolve organic matter.

Treatment:

Drug: Sodium Hypochlorite