Comparison of Aortic Root Dimension Changes During Cardiac Cycle Between the Patients With and Without Aortic Valve Calcification Using ECG-gated 64-slice and Dual-source 256-slice Computed Tomography Scanners: Results of a Multicenter Study

Modarres Hospital

Status: Completed

Conditions: Aortic Valve Calcification

Study type: Observational

Funder types: Other

Identifiers

NCT01755806

ModarresH_001

Details and patient eligibility

About

This study seeks to compare aortic dimension changes during cardiac cycle in patients with and without aortic valve calcification and to evaluate its correlation with aortic valve calcium score in former group.

Full description

The study population comprised 104 patients referred to three cardiac imaging centers for coronary multislice computed tomography, including 52 patients with aortic valve calcification as the study group and 52 subjects without evidence of calcification in their aortic valve, who served as a control group. Data were reconstructed at each 10% of RR-interval during the cardiac cycle and reconstructed images at 30-35% and 70-75% of R-R intervals were obtained, representing systole and diastole, respectively. For diastolic phase, in most cases images at 70% were acquired. Thereafter, acquired images were transferred to a single remote workstation for post-processing and subsequent off-line analysis.

Enrollment: 104 patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients referring for multislice coronary computed tomography for any reason

Exclusion criteria

• Arrhythmia
• Hypertrophic cardiomyopathy
• Aneurysm formation of ascending aorta
• Marfan's disease
• Ehlers-Danlos syndrome
• History of coronary artery bypass surgery
• History of coronary stenting
• Aortic valve surgery
• Thoracic aorta surgery
• Aortic valve stenosis

Trial design

104 participants in 2 patient groups

aortic root dimension change

Description:

those without aortic valve calcification

aortic root dimension change, aortic valve calcium score

Description:

those with aortic valve calcification