Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth

Taibah University

Status and phase: Completed; Phase 4

Conditions: Dental Extraction; Maxillary Teeth; Overcoming the Failure of Anaesthesia

Treatments: Drug: Prilocain 3%; Drug: Articaine 4%; Drug: Felypressin; Drug: Adrenalin

Study type: Interventional

Funder types: Other

Identifiers

NCT04236115

Taibah dental College

Details and patient eligibility

About

Ninety-five patients, aged between 16 and 70 years old, were included in this study. Patients were divided into two groups. Group one received Articaine 4% with 1:00.000 Adrenalines. Group two received Prilocaine with 3% Felypressin (0.03 I.U. per ml). Onset time of anaesthesia was objectively evaluated by using electronic pulp testing.

Full description

85 patients in this study had successful local anaesthetic followed by extraction within the study duration time (10 minutes). However, there were six patients with failure anaesthesia (5 in prilocaine group and 1 in articaine group). By application Person's Chi-square test (x2), there were no significant differences in the number of the episodes of the anaesthetic success between articaine and prilocaine groups at time intervals (P-value = 0.5). T- test showed there have been no important variations within the mean onset time of anaesthesia for articaine and prilocaine buccal infiltrations (P-value =0.1).

Enrollment: 95 patients

Sex: All

Ages: 16 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients have one or two upper teeth for extraction, subject tooth or its adjacent must be vital, healthy patient or patient with mild systemic diseases (class I or II according to American Society of Anesthesiology).

Exclusion criteria

• Patients excluded from this study if they have allergy to local anaesthetic agents or need surgical, or multiple teeth extraction.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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95 participants in 2 patient groups

Articaine 4% with 1:00.000 Adrenaline

Active Comparator group

Description:

if the patient was in articaine group, buccal infiltration technique was applied by inserting a short needle at the height of buccal sulcus along the long axis of the subject tooth for extraction.

Treatment:

Drug: Adrenalin

Drug: Articaine 4%

Prilocaine with 3% Felypressin (0.03 I.U. per ml)

Active Comparator group

Description:

if the patient was in prelocaine group, buccal infiltration technique was applied by inserting a short needle at the height of buccal sulcus along the long axis of the subject tooth for extraction.

Treatment:

Drug: Felypressin

Drug: Prilocain 3%