Comparison of Ascorbic Acid and Grape Seed Extract in Oxidative Stress Induced by on Pump Heart Surgery

Tabriz University

Status: Unknown

Conditions: CABG-Induced Oxidative Stress

Treatments: Drug: Vit C (Ascorbic Acid); Drug: GSE

Study type: Interventional

Funder types: Other

Identifiers

NCT00839085

8710

Details and patient eligibility

About

Study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.

Full description

This study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.

There are three groups in the study. 75 candidate of coronary artery by pass grafting surgery were assigned random allocation on the groups (25 in each group).

1. Control
2. GSE (100 mg/6h - PO, 24h before surgery)
3. Vit C (25 mg/kg in pump circulation during surgery)

Enrollment: 72 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Candidates for elective CABG surgery with pump for first time
• 3VD

Exclusion criteria

• High risk patients
• Those who need another heart surgery beside CABG
• Urgent patients
• Diabetics
• Ischemic time more than 120 min

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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72 participants in 3 patient groups

1

No Intervention group

Description:

normal procedure of CABG

2: GSE

Active Comparator group

Description:

100 mg GSE every 6h /Po, starting one day before surgery (4 doses in 24h)

Treatment:

Drug: GSE

3: Vit C

Active Comparator group

Description:

25 mg/kg through pump

Treatment:

Drug: Vit C (Ascorbic Acid)