Comparison of Atrophogenic Effect of Hydrocortison 1% Cream and Pimecrolimus 1% Cream Assessed by Optical Coherence Tomography (OCT) and 20-MHz Ultrasound of Uninvolved Skin in Patients With Atopic Dermatitis (OCT-AD)

Technische Universität Dresden

Status and phase: Completed; Phase 2

Conditions: Atopic Dermatitis

Treatments: Drug: pimecrolimus 1% cream; Drug: hydrocortison 1% cream

Study type: Interventional

Funder types: Other

Identifiers

NCT00610142

TUD-OCT-AD-025

Details and patient eligibility

About

to explore the atrophogenic potentials of hydrocortison 1% cream and pimecrolimus 1% cream on unaffected forehead skin

Enrollment: 20 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-60 years
• diagnosis of atopic dermatitis (Hanifin & Rajka Criteria)
• patients with atopic dermatitis not affecting the forehead

Exclusion criteria

• pregnancy / nursing mothers
• women in reproductive age without adequate contraception
• severe atopic dermatitis (IGA >= 4)
• UV-Therapy in past 4 weeks
• patients receiving any topical treatment on the face in past 6 month

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

1

Active Comparator group

Treatment:

Drug: pimecrolimus 1% cream

2

Active Comparator group

Treatment:

Drug: hydrocortison 1% cream