Comparison of Autologous Serum and Umbilical Cord Serum Eyedrops for Dry Eye Syndrome

Chonnam National University

Status

Completed

Conditions

Dry Eye Syndrome

Treatments

Drug: Autologous serum eyedrops

Drug: Umbilical cord serum eyedrops

Study type

Interventional

Funder types

Other

Identifiers

NCT00442273

UCS-0001

Details and patient eligibility

About

To compare the therapeutic effect between autologous serum and umbilical cord serum eyedrops in the treatment of severe dry eye syndrome.

Full description

Ninety-two eyes of 48 patients with severe dry eye syndrome (34 eyes of 17 patients with Sjögren's syndrome and 58 eyes of 31 patients with non-Sjögren's syndrome) were treated with either 20% autologous serum (41 eyes of 21 patients) or umbilical cord serum eyedrops (51 eyes of 27 patients). Symptom scoring, corneal sensitivity test, tear film break-up time (BUT), Schirmer test, tear clearance rate (TCR), corneal fluorescein staining, and conjunctival impression cytology were performed before and 1 month and 2 months after treatment.

Sex

All

Ages

20 to 61 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with severe dry eye syndrome who were refractory to conventional treatments and had symptoms of dry eye for more than 3 months
Low tear film break-up time (BUT, < 5 sec)
Low Schirmer test (5 mm)
Positive fluorescein or rose bengal vital staining (≥ 3)

Exclusion criteria