Comparison of Balanced Crystalloids and Normal Saline in Septic Patients

ZhiYong Peng

Status: Unknown

Conditions: Acute Kidney Injury; Sepsis, Severe; Septic Shock; Sepsis

Treatments: Drug: 0.9% saline; Drug: lactated Ringer's solution

Study type: Interventional

Funder types: Other

Identifiers

NCT03685214

2018010

Details and patient eligibility

About

In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal saline, and provide evidence for current fluid resuscitation strategies for sepsis.

Full description

During the study period，either normal saline or acetated Ringer's solution will be assigned as resuscitation fluid to the septic patients meeting the inclusion criteria.It is anticipated that about 500 patients will be enrolled during the study period.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed sepsis aged 18~75 and accepted therapy in ICU

Exclusion criteria

• Need of Renal replacement treatment
• End-stage renal failure
• pregnant woman

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

500 participants in 2 patient groups

0.9% saline

Experimental group

Description:

We use 0.9% saline for resuscitation fluid in ICU septic patients

Treatment:

Drug: 0.9% saline

Balanced Crystalloids

Experimental group

Description:

We use acetated Ringer's solution for resuscitation fluid in ICU septic patients

Treatment:

Drug: lactated Ringer's solution