Comparison of Biochemical Changes in Patients With Trochanteric Region Fracture Fixation With DHS Versus PFN

Kushtrim Grezda

Status: Completed

Conditions: Hip Fractures

Treatments: Procedure: Proximal Femoral Nail; Procedure: Dynamic Hip Screw

Study type: Interventional

Funder types: Other

Identifiers

NCT03849014

KGrezda

Details and patient eligibility

About

Hip fractures are one of the most frequent fractures in older adults. There is still controversy which surgical strategy is the best option for treatment of hip fractures especially trochanteric region fractures. Surgical intervention that follows hip fracture induces biochemical, physiological and fibrinolytic changes that are so-called "second hit phenomenon" which trigger systemic inflammatory response syndrome. The investigators are aiming to study this phenomenon after two different surgical procedures and help surgeons in everyday practice to choose the most suitable surgical treatment for patients with trochanteric region fracture and give the scientific community more evidence which methods is better since there is still controversy.

Enrollment: 60 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with trochanteric region fractures AO/OTA 31.A1-31.A2
• Time from fracture till surgery up to 1 week
• American Society of Anesthesiologists Classification (ASA) I-III
• Willing to participate

Exclusion criteria

• Polytrauma patients
• Open fractures
• Existing local or systemic infection
• Pre-existing coagulatory disorder
• Existing malignancy
• Corticosteroid use
• Systemic inflammatory disease
• Voluntary withdraws of the patient

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Dynamic Hip Screw

Active Comparator group

Description:

Dynamic Hip Screw is used for internal fixation of fractures of the certain types of hip fractures. The implant assembly consisting of a lag screw, a side plate, and cortical screws that fix the side plate to the proximal femoral shaft.

Treatment:

Procedure: Dynamic Hip Screw

Proximal Femoral Nail

Active Comparator group

Description:

The Proximal Femoral Nail offers osteosynthesis for the several types of hip fractures. It consists of an anatomically curved nail, double neck screw, and two locking screws for distal end.

Treatment:

Procedure: Proximal Femoral Nail